The clinics of HHV-6 infection in COVID-19 pandemic: Pityriasis rosea and Kawasaki disease. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. At first, I thought it could be a fungal infection like ringworm, a common misdiagnosis, says Hartman, but my dermatologist ruled that out when I mentioned the additional spots erupting on my back via our video chat. Pityriasis rosea is also known as Christmas tree rash. Dermatol Online J. Medicines (Basel). National Library of Medicine 78 PDF Pityriasis rosea following CoronaVac COVID19 vaccination: a case report Elin Akda, N. Ilter, B. t, . Erdem However, if you scratch your patches, you may break your skin, leading to an infection that can cause pain. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. . Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. Bookshelf Figure 1. What started as a single, quarter-inch raised welt on my left rib cage eventually morphed into two, then four. An official website of the United States government. See this image and copyright information in PMC. doi: 10.1111/bjd.20143. Before eCollection 2022 Jul. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). Pityriasis rosea-like eruption revealing COVID-19. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. eCollection 2021. Cutis. 1. government site. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. However, a fungus causes ringworm. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). This site needs JavaScript to work properly. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. "And it has a particular [dermatomal] distribution because it's along a nerve," which also presents as fluid-filled blisters, rather than lesions. eCollection 2022. Some people who have had cosmetic fillers used to remove . 2021 Aug;35(8):e491-e493. "There's some emerging data where there are certain skin rashes that seem to be more associated with the COVID vaccine, and pityriasis rosea is one them. Disclaimer. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. How can you tell that I have pityriasis rosea? Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Cutis. Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. An official website of the United States government. Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. doi: 10.1002/jmv.26549, 9. Authors B M Cyrenne 1 , F Al-Mohammedi 1 , J G DeKoven 1 , R Alhusayen 1 Affiliation -, Broccolo F, Drago F, Careddu AM, et al. Apply a moisturizer, calamine lotion or a nonprescription . Unauthorized use of these marks is strictly prohibited. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. This reaction is self-limited and resolves in an average of 5.6 weeks. 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. The herald patch is the telltale sign that your rash could be PR, but there are other common (though not universal) symptoms as well. (2020) 83:e5760. However, the studies dont conclusively prove that COVID-19 causes pityriasis rosea. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. Federal government websites often end in .gov or .mil. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Pityriasis rosea is a common condition that causes discolored patches on your skin. Disclaimer. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. J Eur Acad Dermatol Venereol. This site needs JavaScript to work properly. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. However, there isnt enough research to determine that stress may cause pityriasis rosea. (b) haematoxylineosin, original magnification 20. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. Once its gone, you likely wont develop it again. Before We present the case of a female patient in whom the diagnosis of pityriasis rosea led to the investigation and diagnosis of the SARS-CoV-2 infection. HHS Vulnerability Disclosure, Help The https:// ensures that you are connecting to the Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. doi: 10.1016/j.jdcr.2018.04.002, 12. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. HHS Vulnerability Disclosure, Help Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . doi: 10.1111/bjd.20143. Epub 2022 Feb 9. The evolution was unfavorable, with the spread of the lesions and the accentuation of the pruritus. The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. Moreover, COVID-19 may solely induce human herpesvirus reactivation through the immunomodulatory ability of SARS-CoV-2 to reactivate latent viruses (8, 9). and transmitted securely. Would you like email updates of new search results? 2023 Cond Nast. However, pityriasis rosea can look similar to other skin conditions, including: If theres any doubt, your healthcare provider may perform the following tests: In most cases, pityriasis rosea goes away without any treatment in six to eight weeks. Khalili M, Abtahi-Naeini B, Rastegarnasab F, Afshar K. Clin Case Rep. 2022 Jul 19;10(7):e6096. Conflicts of Interests: The authors declare there are no competing interests. This tiny glimpse of her natural texture is thrilling. KL drafted the original manuscript. I also had to stop working out and hiking for about a week, as Alexiades is right excessive perspiration worsened the itch. . Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. 2021;184(6):11941195. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. Unable to load your collection due to an error, Unable to load your delegates due to an error. Published by Elsevier Inc. Pityriasis rosea. The site is secure. The study said the appearance was similar to pityriasis rosea, a common skin condition. Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. The authors have no conflicts of interests to disclose. Front. 8600 Rockville Pike 8600 Rockville Pike Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders. Clinical aspect of the lesions after 7 days of treatment. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Before Dermatol Ther. (b) Patient 1: Closeup of a plaque. Some treatments can alleviate related symptoms, including itching. Epub 2021 May 29. These patches are smaller than the herald patch they range from 1 to 2 cm and are often called daughter patches. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. (2019) 34:185764. National Library of Medicine (2015) 2015:253154. doi: 10.1155/2015/253154, 14. Bookshelf Pityriasis rosea Gibert type rash in an asymptomatic patient that tested positive for COVID-19. PMC COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Med Clin (Barc). Please enable it to take advantage of the complete set of features! Pityriasis rosea and ringworm look similar. J Am Acad Dermatol. Unauthorized use of these marks is strictly prohibited. Drago F, Ciccarese G, Rebora A, Parodi A. Use of this site constitutes acceptance of our Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Had I started new medication? 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. Br J Dermatol. Authors Elina Khattab 1 , Eirini Christaki 2 , Constantinos Pitsios 1 Affiliations 1 Medical School, University of Cyprus, Nicosia, Cyprus. . Pityriasis rosea following SARS-CoV-2 vaccination: A case series. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 2021 Nov;35(11):e721-e722. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). It is usually seen in children, adolescents, and young adults. Before doi: 10.1111/jdv.17498. Accessibility sharing sensitive information, make sure youre on a federal Please enable it to take advantage of the complete set of features! Pityriasis Lichenoides. FOIA J Med Virol. J Am Acad Dermatol. Keywords: Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Drago F, Ciccarese G, Javor S, et al. As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. Br J Dermatol. sharing sensitive information, make sure youre on a federal A 3-cm oval plaque with peripheral scale, larger, MeSH If I dont have pityriasis rosea, what other skin condition might I have? doi: 10.12998/wjcc.v5.i6.203, 6. You may initially develop a fever, headache or upper respiratory infection. The condition is more prevalent in spring and fall. Federal government websites often end in .gov or .mil. Please enable it to take advantage of the complete set of features! J Eur Acad Dermatol Venereol 2020;34:e2123. Safety and efficacy of the BNT162b2 mRNA Covid19 vaccine. Epub 2022 Jun 19. You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). Epub 2021 Jul 21. (2021) p. e15040. Pityriasis rosea Gibert is an erythematous-papulosquamous dermatosis that frequently occurs in young adults. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. This site needs JavaScript to work properly. ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). Disclaimer. Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. Get many smaller patches or bumps on your skin. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Diagnostic and prognostic values of cutaneous manifestations in COVID-19. doi: 10.7759/cureus.22414. 2021 Jun 25;118(25):431. doi: 10.3238/arztebl.m2021.0257. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Figure 2. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. Bookshelf doi: 10.1016/j.jaad.2020.04.094, 8. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Advertising on our site helps support our mission. J Eur Acad Dermatol Venereol. (2020) 33:e13650. 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. Pityriasis rosea and pityriasis rosea-like eruptions after COVID-19 vaccines. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). (2006) 12:1. doi: 10.5070/D380D8301D, 11. Nevertheless, she did not present with fever or respiratory tract symptoms. Previously, PR has been reported in temporal association with various viral inoculations. retailers. -. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Disclaimer. Br J Dermatol. official website and that any information you provide is encrypted Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 Epub 2021 Nov 2. Table 1. Bethesda, MD 20894, Web Policies J Med Virol 2021; 93: 1850-1851. -, Broccolo F., Drago F., Careddu A.M., et al. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). 8 In some cases, antibodies against HHV6/7 as well as viral DNA in plasma and PBMCs were detected. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. -, Mahajan K, Relhan V, Relhan AK, et al. Women and young people are most likely to have these reactions. Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. doi: 10.7759/cureus.27108. Herald patch of pityriasis rosea. 2022 Jul 8;101(27):e29823. Vote for your favorite beauty products now! It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). NCI CPTC Antibody Characterization Program. doi: 10.1111/jdv.17342. Herald patch in the right hypochondrium followed by typical oval-shaped secondary plaques, Pityriasis rosea lesions on the upper extremities, MeSH Lawley LP, McCall CO, Lawley TJ. (c) Patient 2: Thin red to tan oval plaques with peripheral scale on the trunk and proximal thigh. J Eur Acad Dermatol Venereol. Inverse pityriasis rosea secondary to COVID-19 vaccination. Would you like email updates of new search results? Pityriasis lichenoides has distinct acute and chronic forms, which are usually distinct . 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Epub 2021 Nov 2. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. Some people see the rash disappear within 6 to 8 weeks, but it can take 5 months or longer for the skin to clear. 2022 Aug;20(8):1123-1124. doi: 10.1111/ddg.14784. Dermatol Reports. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). For most people, it resolves without treatment. 2021;35(8):e489e491. Bethesda, MD 20894, Web Policies JAAD Case Rep. 2021;7:9394. The Covid Symptom Study. official website and that any information you provide is encrypted
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